Sulfuric Acid → HCID 12281154、化合物
反応式
[C:1]([C:9]1[C:10]([O:24][CH2:25][CH3:26])=[C:11]2[CH:17]=[N:16][N:15](CC3OC=CC=3)[C:12]2=[N:13][CH:14]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(=O)(=O)(O)O>O>[C:1]([C:9]1[C:10]([O:24][CH2:25][CH3:26])=[C:11]2[CH:17]=[N:16][NH:15][C:12]2=[N:13][CH:14]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
87 g. of 5-benzoyl-4-ethoxy-1-(2-furanyl)methyl-1H-pyrazolo[3,4-b]pyridine (0.25 mol.) are dissolved in 300 ml. of conc. sulfuric acid within 15 to 20 minutes with vigorous stirring. The temperature rises to 40°-45°. Stirring is continued for 1 hour. The dark colored mixture is then added to 3700 ml. of cold water. Stirring is continued for 2 hours and the dark by-products are filtered off. The filtrate is made alkaline with 25% aqueous ammonia. The white precipitate of 5-benzoyl-4-ethoxy-1H-pyrazolo[3,4-b]pyridine is filtered off, yield 44.8 g. (66%), m.p. 202°-203° (butanol).