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N-methylhydroxylamine hydrochloride → alpha-(1-Methyl-2-nitroimidazole-5-yl)-N-methylnitrone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-methylhydroxylamine hydrochloride | HCID 77906 | — |
| 反応物 | 1-Methyl-2-nitro-1H-imidazole-5-carboxaldehyde | HCID 100390 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | alpha-(1-Methyl-2-nitroimidazole-5-yl)-N-methylnitrone | HCID 325650 | — |
反応手順
A mixture of 0.250 g. of 1-methyl-2-nitro-5-imidazolecarboxaldehyde, 0.150 g. of N-methylhydroxylamine hydrochloride and 0.150 g. of sodium bicarbonate is refluxed in 80 ml. of anhydrous ethanol for 2 hours and after filtration is concentrated to small volume. The title compound crystallizes on cooling. Yield: 0.24 g, m.p. 208°-209° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US03987053 |
| 出典データセット | uspto-grants-1976_10 |
| ORD ID | ord-2752f34f108c41339ac7b1ed499c1c8c |
| 出典メモ | uspto-grants-1976_10 |