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Phenylacetylene → 4-(Phenylethynyl)benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenylacetylene | HCID 10821 | — |
| 反応物 | 4-Bromobenzaldehyde | HCID 70741 | — |
| 触媒 | Palladium(2+) acetate--triphenylphosphane (1/2/2) | HCID 84538 | — |
| 生成物 | 4-(Phenylethynyl)benzaldehyde | HCID 609908 | 70% |
反応手順
By the method of example 53(A), but using bis(triphenylphosphine)palladium(II) acetate as catalyst (3 mol %), phenylacetylene and 4-bromobenzaldehyde are coupled to give 4-(2-phenylethynyl)benzaldehyde in 70% yield after distillation. By the methods of example 1, this is converted into the title compound, obtained as a colorless solid, mp 190°-191° after recrystallization from hexane-ethyl acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05464865 |
| 出典データセット | uspto-grants-1995_11 |
| ORD ID | ord-843acba50177435e8a47409e0d2ace33 |
| 出典メモ | uspto-grants-1995_11 |