Hydrochloric Acid → 11-Chloro-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline dihydrochloride

反応式

[Cl:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:12][CH2:13][N:14](C(OCC)=O)[CH2:15][CH2:16][C:3]=12.[ClH:22].C1(N)C(F)=C(F)C(F)=C(N)C=1F.Cl.Cl>>[ClH:1].[ClH:22].[Cl:1][C:2]1[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[N:5]=[C:4]2[CH2:12][CH2:13][NH:14][CH2:15][CH2:16][C:3]=12

参加物

反応物 3

HCID 313Hydrochloric Acid

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride

HCID 2150364411-chloro-3-ethoxycarbonyl-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline

生成物 1

HCID 2150348411-Chloro-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline dihydrochloride

実験手順

11-Chloro-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline dihydrochloride was prepared by hydrolysis of 11-chloro-3-phenoxycarboxyl-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline or 11-chloro-3-ethoxycarbonyl-1,2,4,5-tetrahydro-3H-azepino[4,5-b]quinoline with concentrated hydrochloric acid. Yield of the dihydrochloride: 69% of theory; m.p. 261° C. (decomp.).

出典と根拠

ORDレコード: ord-5e0dda2e6a54476581991fa57dbd19ce
出典データセット: uspto-grants-1976_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US03987047

反応ノート

読み込み中…

参加物