3-(5-Methoxynaphthalen-2-yl)prop-2-ynoic acid → HCID 21504103、化合物

HRID 1288212ノート

反応式

HRID 1288212 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[CH:6][C:7]([C:13]#[C:14]C(O)=O)=[CH:8]2>N1C2C(=CC=CC=2)C=CC=1.O>[C:13]([C:7]1[CH:6]=[CH:5][C:4]2[C:9](=[CH:10][CH:11]=[CH:12][C:3]=2[O:2][CH3:1])[CH:8]=1)#[CH:14]

参加物

4

反応物 1

HCID 215040793-(5-Methoxynaphthalen-2-yl)prop-2-ynoic acid

生成物 1

HCID 21504103HCID 21504103、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 7047Quinoline溶媒

実験手順

5-methoxynaphth-2-ylpropiolic acid (5.85) is heated at 120-124° for 5 hours in quinoline. The reaction product is diluted with water and washed thoroughly with dilute hydrochloric acid. This is followed by washing with sodium bicarbonate (10%). The material is passed through a short aluminum (H+) column, eluted with N-hexane to give a fraction free of carbonyl absorption (I.R.). Removal of solvent gives 2-ethynyl-5-methoxynaphthalene.

後処理

  1. washwashed thoroughly with dilute hydrochloric acid
  2. washby washing with sodium bicarbonate (10%)
  3. washeluted with N-hexane
  4. customto give a fraction
  5. customfree of carbonyl absorption (I.R.)
  6. customRemoval of solvent

出典と根拠

ORDレコード
ord-1fd03c315e6044288f18d467addd3acb
出典データセット
uspto-grants-1976_10
特許番号
US03987116

反応ノート

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