Water → HCID 178427642、化合物

反応式

I.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](=[NH:13])SC)=[CH:5][CH:4]=1.[C:14]1([CH3:24])[CH:19]=[CH:18][C:17]([S:20]([O-:23])(=[O:22])=[O:21])=[CH:16][CH:15]=1.[Na+].[OH2:26]>CCOCC>[C:14]1([CH3:24])[CH:15]=[CH:16][C:17]([S:20]([OH:23])(=[O:21])=[O:22])=[CH:18][CH:19]=1.[CH3:24][C:14]1[CH:19]=[C:18]([CH:17]=[CH:16][CH:15]=1)[O:26][CH:9]([CH3:6])[CH2:10][NH:13][C:10](=[NH:13])[CH2:9][C:6]1[CH:7]=[CH:8][C:3]([Cl:2])=[CH:4][CH:5]=1

参加物

実験手順

The reaction between methyl 4-chlorophenyl(thioacetimidate)hydriodide (3.7 g.) and 2-3'-methylphenoxypropylamine (1.7 g.) was carried out as in Example 78, except that the reaction solution was diluted, not with ether, but with 2N-aqueous sodium p-toluenesulphonate (5.5 ml.) followed by water. The resulting crystalline product was recrystallised from a mixture of ethanol and ether, and then from a mixture of acetone and water, to give N-(2-3'-methylphenoxypropyl)-4-chlorophenylacetamidine p-toluenesulphonate, m.p. 145°-147°, undepressed on admixture with the product of Example 29.