HCID 21950481、化合物 → 2-(Methanesulfonyl)benzonitrile

HRID 1288266ノート

反応式

HRID 1288266 の反応式
[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]([NH2:9])=O)(=[O:4])=[O:3]>P(Cl)(Cl)(Cl)=O>[CH3:1][S:2]([C:5]1[CH:13]=[CH:12][CH:11]=[CH:10][C:6]=1[C:7]#[N:9])(=[O:3])=[O:4]

参加物

3

反応物 1

HCID 21950481HCID 21950481、化合物

生成物 1

HCID 223462902-(Methanesulfonyl)benzonitrile収率 87.3%

試薬・触媒・溶媒 1

HCID 24813Phosphorus oxychloride溶媒

実験手順

2-Methanesulphonylbenzamide (34 g.) was added to phosphorus oxychloride (100 ml.) and the mixture was refluxed for 90 minutes. The excess of phosphorus oxychloride was evaporated in vacuo, and the oily residue was treated with water (200 ml.), with ice cooling. The solid which separated was filtered off, washed with water and recrystallised from ethanol to give 2-methanesulphonylbenzonitrile (27 g.), m.p. 105°-106° C.

後処理

  1. temperaturethe mixture was refluxed for 90 minutes
  2. customThe excess of phosphorus oxychloride was evaporated in vacuo
  3. additionthe oily residue was treated with water (200 ml.), with ice cooling
  4. customThe solid which separated
  5. filtrationwas filtered off
  6. washwashed with water
  7. customrecrystallised from ethanol

出典と根拠

ORDレコード
ord-394b98742ce743418c8da40afff7a674
出典データセット
uspto-grants-1976_10
特許番号
US03987160

反応ノート

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