Ethyl 7-bromoheptanoate → ethyl 7-[N-(4-acetoxynonyl)-acrylamido]heptanoate
反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9].BrCCCCCC(C)C(OC)=[O:21].[O:25]1CCC[CH2:27][CH:26]1[O:31][CH:32]([CH2:51][CH2:52][CH2:53][CH2:54][CH3:55])[CH2:33][CH2:34][CH2:35][N:36]([CH2:40][CH2:41][CH2:42]CCC(C)C(OC)=O)C(=O)C>>[C:26]([O:31][CH:32]([CH2:51][CH2:52][CH2:53][CH2:54][CH3:55])[CH2:33][CH2:34][CH2:35][N:36]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][C:8]([O:10][CH2:11][CH3:12])=[O:9])[C:40](=[O:21])[CH:41]=[CH2:42])(=[O:25])[CH3:27]参加物
4
実験手順
The synthesis of this compound is carried out as described in Exanple 1 except that, in Step A, the ethyl 7-bromoheptanoate is replaced by an equimolar amount of methyl 7-bromo-2-methylheptanoate (Example L, Step 4). The product of Step A is methyl 7-{N-[4-(2-tetrahydropyranyloxy)nonyl]acetamido}-2-methylheptanoate. The subsequent step yields 7-[N-(4-hydroxynonyl)acetamido]-2-methylheptanoic acid (B).