Ammonium Hydroxide → 2-Acetyl-7-chloro-8-sulfamyl-1,2,3,4-tetrahydroisoquinoline

HRID 1288462ノート

反応式

HRID 1288462 の反応式
[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[C:7]([S:15](Cl)(=[O:17])=[O:16])[C:8]([Cl:14])=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2].[OH-].[NH4+:20]>>[C:1]([N:4]1[CH2:13][CH2:12][C:11]2[C:6](=[C:7]([S:15](=[O:17])(=[O:16])[NH2:20])[C:8]([Cl:14])=[CH:9][CH:10]=2)[CH2:5]1)(=[O:3])[CH3:2]

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 128380412-Acetyl-8-chlorosulfonyl-7-chloro-1,2,3,4-tetrahydroisoquinoline

生成物 1

HCID 213938002-Acetyl-7-chloro-8-sulfamyl-1,2,3,4-tetrahydroisoquinoline

実験手順

2-Acetyl-8-chlorosulfonyl-7-chloro-1,2,3,4-tetrahydroisoquinoline (0.022 mole) is treated with concentrated ammonium hydroxide (30 ml.) with cooling. The resulting solid is filtered off and washed with water to give 2-acetyl-7-chloro-8-sulfamyl-1,2,3,4-tetrahydroisoquinoline.

後処理

  1. temperaturewith cooling
  2. filtrationThe resulting solid is filtered off
  3. washwashed with water

出典と根拠

ORDレコード
ord-2ee43315900d40d892c042e4c4ba63e7
出典データセット
uspto-grants-1976_10
特許番号
US03988339

反応ノート

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