Water → 2,3-Dichloro-4-trifluoromethoxybenzoic acid

HRID 1288722ノート

反応式

HRID 1288722 の反応式
[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([O:12][C:13]([F:16])([F:15])[F:14])[CH:8]=[CH:7][C:3]=1[C:4](F)=[O:5].[OH2:17]>>[Cl:1][C:2]1[C:10]([Cl:11])=[C:9]([O:12][C:13]([F:16])([F:15])[F:14])[CH:8]=[CH:7][C:3]=1[C:4]([OH:17])=[O:5]

参加物

3

反応物 2

HCID 962WaterHCID 539612062,3-Dichloro-4-trifluoromethoxybenzoyl fluoride

生成物 1

HCID 543779072,3-Dichloro-4-trifluoromethoxybenzoic acid

実験手順

A suspension of crude 2,3-dichloro-4-trifluoromethoxybenzoyl fluoride (2 g, containing mixed antimony halides) in water was stirred vigorously for 24 hours. The mixture was extracted with dichloromethane and filtered. The organic layer was washed with hydrochloric acid (2M), aqueous sodium chloride solution and extracted into sodium carbonate solution (2M). The aqueous extract was acidified to pH 1 and the solid was filtered off and washed with water to give 2,3-dichloro-4-trifluoromethoxybenzoic acid (0.6 g) as a white solid mp 123°-126° C.

後処理

  1. extractionThe mixture was extracted with dichloromethane
  2. filtrationfiltered
  3. washThe organic layer was washed with hydrochloric acid (2M), aqueous sodium chloride solution
  4. extractionextracted into sodium carbonate solution (2M)
  5. extractionThe aqueous extract
  6. filtrationthe solid was filtered off
  7. washwashed with water

出典と根拠

ORDレコード
ord-20f8929b3f054551a66837e507bfa763
出典データセット
uspto-grants-1998_05
特許番号
US05747424

反応ノート

読み込み中…