2-Bromophenol → 1-Bromo-2-(2-methylpropoxy)benzene

HRID 1289178ノート

反応式

HRID 1289178 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].C([O-])([O-])=O.[K+].[K+].I[CH2:16][CH:17]([CH3:19])[CH3:18]>CC(C)=O>[CH2:16]([O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Br:1])[CH:17]([CH3:19])[CH3:18]

参加物

5

反応物 3

HCID 72442-BromophenolHCID 10556Isobutyl iodideHCID 11430Potassium Carbonate

生成物 1

HCID 189257731-Bromo-2-(2-methylpropoxy)benzene収率 25%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 2-bromophenol (0.67 ml, 5.8 mmol) in 25 ml acetone was added K2CO3 (2.0 g, 14.5 mmol) and 1-iodo-2-methylpropane (0.75 ml, 6.4 mmol). The reaction mixture was heated to reflux for 19 h, cooled to ambient temperature and filtered. The solvent was removed under reduced pressure and the residue was taken up in EtOAc. The organic phase was washed with 1N NaOH×2, water and brine. Drying over Na2 SO4 afforded 330 mg (25%) of 2-isobutoxybromobenzene.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 19 h
  3. filtrationfiltered
  4. customThe solvent was removed under reduced pressure
  5. washThe organic phase was washed with 1N NaOH×2, water and brine
  6. customDrying over Na2 SO4

出典と根拠

ORDレコード
ord-1a858d066ef94350b5e480fb11b0bdcb
出典データセット
uspto-grants-1998_05
特許番号
US05747540

反応ノート

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