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Pentafluorophenol → Pentafluorophenyl o-fluoro-p-[N-((6RS)-2-methyl-4-oxo-3-pivaloyloxymethyl-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)amino]benzoate

HRID 1289223
ノート
印刷プレビュー

反応式

HRID 1289223 の反応式
[F:1][C:2]1[CH:10]=[C:9]([NH:11][CH:12]2[C:16]3[CH:17]=[C:18]4[C:23](=[CH:24][C:15]=3[CH2:14][CH2:13]2)[N:22]=[C:21]([CH3:25])[N:20]([CH2:26][O:27][C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30])[C:19]4=[O:34])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[F:35][C:36]1[C:41](O)=[C:40]([F:43])[C:39]([F:44])=[C:38]([F:45])[C:37]=1[F:46].ON1C2C=CC=CC=2N=N1>C(Cl)Cl>[F:1][C:2]1[CH:10]=[C:9]([NH:11][CH:12]2[C:16]3[CH:17]=[C:18]4[C:23](=[CH:24][C:15]=3[CH2:14][CH2:13]2)[N:22]=[C:21]([CH3:25])[N:20]([CH2:26][O:27][C:28](=[O:33])[C:29]([CH3:30])([CH3:32])[CH3:31])[C:19]4=[O:34])[CH:8]=[CH:7][C:3]=1[C:4]([O:6][C:41]1[C:40]([F:43])=[C:39]([F:44])[C:38]([F:45])=[C:37]([F:46])[C:36]=1[F:35])=[O:5]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 13041PentafluorophenolHCID 757711-HydroxybenzotriazoleHCID 19066365o-Fluoro-p-[N-((6RS)-2-methyl-4-oxo-3-pivaloyloxymethyl-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)amino]benzoic acid

生成物 1

HCID 19066345Pentafluorophenyl o-fluoro-p-[N-((6RS)-2-methyl-4-oxo-3-pivaloyloxymethyl-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)amino]benzoate

試薬・触媒・溶媒 1

HCID 6344
Dichloromethane
溶媒

実験手順

A mixture of o-fluoro-p-[N-((6RS)-2-methyl-4-oxo-3-pivaloyloxymethyl-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)amino]-benzoic acid (0.75 g), pentafluorophenol (1.77 g), N,N-dicyclohexylcarbodiimide (0.66 g), N-hydroxybenzotriazole (0.01 g) and methylene chloride (100 ml) was stirred at ambient temperature for 18 hours. The mixture was filtered and the filtrate was evaporated. The residue was purified by column chromatography using increasingly polar mixtures of hexane and ethyl acetate as eluant. There was thus obtained pentafluorophenyl o-fluoro-p-[N-((6RS)-2-methyl-4-oxo-3-pivaloyloxymethyl-3,4,7,8-tetrahydro-6H-cyclopenta[g]quinazolin-6-yl)amino]benzoate as a gum (0.72 g);

後処理

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customThe residue was purified by column chromatography
  4. temperatureusing increasingly polar mixtures of hexane and ethyl acetate as eluant

出典と根拠

ORDレコード
ord-6be7575db97240039c67d6effab86d2c
出典データセット
uspto-grants-1998_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05747499

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート