Methyl alpha-amino-p-methoxycarbonylmethylphenylacetate → (RS)-alpha-amino-p-carboxymethylphenylacetic acid

HRID 1289240ノート

反応式

HRID 1289240 の反応式
[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([O:16]C)=[O:15])=[CH:9][CH:8]=1)[C:3]([O:5]C)=[O:4]>Cl>[NH2:1][CH:2]([C:7]1[CH:12]=[CH:11][C:10]([CH2:13][C:14]([OH:16])=[O:15])=[CH:9][CH:8]=1)[C:3]([OH:5])=[O:4]

参加物

3

反応物 1

HCID 54294376Methyl alpha-amino-p-methoxycarbonylmethylphenylacetate

生成物 1

HCID 18925125(RS)-alpha-amino-p-carboxymethylphenylacetic acid収率 99%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

A suspension of methyl α-amino-p-methoxycarbonylmethylphenylacetate (2.3 g, 7 mmol) in 60 ml of 6N HCl was refluxed for 12 hours. After cooling white needles were collected. The aqueous layers were extracted with ethyl acetate. The organic layers were evaporated and the solids combined to give (RS)-α-amino-p-carboxymethylphenylacetic acid (1.45 g, 83%);

後処理

  1. temperaturewas refluxed for 12 hours
  2. temperatureAfter cooling white needles
  3. customwere collected
  4. extractionThe aqueous layers were extracted with ethyl acetate
  5. customThe organic layers were evaporated

出典と根拠

ORDレコード
ord-381463ce4d2a42529a84fb8a8dcb4c07
出典データセット
uspto-grants-1998_05
特許番号
US05747499

反応ノート

読み込み中…