HCID 23206558、化合物 → HCID 23206535、化合物
反応式
[CH2:1]([O:3][P:4]([CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:19]([F:22])([F:21])[F:20])[CH:15]=2)[N:10]1C(OCC(Cl)(Cl)Cl)=O)(=[O:8])[O:5][CH2:6][CH3:7])[CH3:2]>CO.[Zn]>[CH2:6]([O:5][P:4]([CH:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([C:19]([F:20])([F:21])[F:22])[CH:15]=2)[NH:10]1)(=[O:8])[O:3][CH2:1][CH3:2])[CH3:7]参加物
4
反応条件
- 温度
- 90 °C
実験手順
15.4 g of 1-(2,2,2-trichloroethoxycarbonyl)-6-trifluoromethyl-1,2,3,4-tetrahydroquinoline-2-phosphonic acid diethyl ester is dissolved in 400 ml of methanol, mixed with 7.2 g of zinc powder and stirred under nitrogen for 1.5 hours at 90° C. It is filtered on diatomaceous earth and the filtrate is concentrated by evaporation. The crude product is purified by column chromatography and recrystallized from isopropyl ether.