Pivaloyl chloride → Nalbuphine pivalate

HRID 1289466ノート

反応式

HRID 1289466 の反応式
[CH:1]1[C:6]2[CH2:7][C@H:8]3[N:13]([CH2:14][CH:15]4[CH2:18][CH2:17][CH2:16]4)[CH2:12][CH2:11][C@:10]45[C@H:19]([C@@H:21]([OH:24])[CH2:22][CH2:23][C@@:9]34[OH:25])[O:20][C:4]([C:5]=25)=[C:3]([OH:26])[CH:2]=1.[C:27](Cl)(=[O:32])[C:28]([CH3:31])([CH3:30])[CH3:29]>C(Cl)Cl>[CH:1]1[C:6]2[CH2:7][C@H:8]3[N:13]([CH2:14][CH:15]4[CH2:18][CH2:17][CH2:16]4)[CH2:12][CH2:11][C@:10]45[C@H:19]([C@@H:21]([OH:24])[CH2:22][CH2:23][C@@:9]34[OH:25])[O:20][C:4]([C:5]=25)=[C:3]([OH:26])[CH:2]=1.[C:27]([O-:32])(=[O:20])[C:28]([CH3:31])([CH3:30])[CH3:29]

参加物

4

反応物 2

HCID 62493Pivaloyl chlorideHCID 5311304Nalbuphine

生成物 1

HCID 86752539Nalbuphine pivalate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

75 mL of methylene chloride and 3.75 g (0.01 mole) of nalbuphine were placed in a 250-mL ice-bathed round-bottomed flask. While stirring, 0.01 mole of pivaloyl chloride dissolved in 20 mL of methylene chloride was added gradually. Following the procedure as described in Example 1, pure nalbuphine pivalate was obtained. The physical data are shown in Table 1 and FIGS. 6, 7 and 8.

後処理

  1. additionwas added gradually

出典と根拠

ORDレコード
ord-2b1094df3d994fc5a56eaef7e40d4eca
出典データセット
uspto-grants-1998_05
特許番号
US05750534

反応ノート

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