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Water → 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Hydroxide | HCID 14797 | — |
| 反応物 | Indole-5-carbonitrile | HCID 27513 | — |
| 反応物 | 1-Methyl-4-piperidone | HCID 74049 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indole-5-carbonitrile | HCID 14973216 | 97.6% |
反応手順
5-Cyanoindole (Aldrich, 20.0 g) was added to a solution of KOH (22.4 g) in methanol (200 ml). N-Methyl-4-piperidone (Aldrich, 40.4 g) was then added dropwise and the resulting mixture refluxed for 4 hours, then cooled and poured into water. The resulting precipitate was filtered off and dried to give the desired product as a pale pink crystalline solid (32.6 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05466699 |
| 出典データセット | uspto-grants-1995_11 |
| ORD ID | ord-928466b98a0c49e2bfc4209e9e3c633b |
| 出典メモ | uspto-grants-1995_11 |