HCID 10339510、化合物 → HCID 10607909、化合物
反応式
NC1N=[C:5]([C:7]2C=[C:11](C(C)(C)C)[C:10](OCOCCOC)=[C:9](C(C)(C)C)[CH:8]=2)[NH:4]N=1.C[O-].[Na+].CO.[C:33]([NH:36][NH2:37])([NH2:35])=[NH:34].[ClH:38]>CO>[NH2:34][C:33]1[N:35]=[C:11]([C:10]2[CH:9]=[CH:8][C:7]([Cl:38])=[CH:5][N:4]=2)[NH:37][N:36]=1参加物
5
実験手順
The synthesis method of Example 7-(2) was applied. The compound (3.94 g) obtained in (3) above, a 5M sodium methoxide-methanol solution (17 ml), methanol (20 ml) and aminoguanidine hydrochloride (9.39 g) were used as reagents. The mixture was stirred with refluxing for 18 hours and methanol was distilled away under reduced pressure. Water was added to the residue and the aqueous layer was adjusted to pH 3-4 with 3N hydrochloric acid to give 3.40 g of a pale-yellow solid that precipitated (yield 82%).
後処理
- temperaturewith refluxing for 18 hours
- distillationmethanol was distilled away under reduced pressure
- additionWater was added to the residue
出典と根拠
- ORDレコード
- ord-611c5913e9194cf5b626e48d685ad9c3
- 出典データセット
- uspto-grants-1998_05
- 特許番号
- US05750545
反応ノート
読み込み中…