Trimethyl orthobeznoate → HCID 10514375、化合物

HRID 1289803ノート

反応式

HRID 1289803 の反応式
[NH2:1][C:2]1[N:6]([C:7]([NH:9][CH3:10])=[S:8])[N:5]=[CH:4][N:3]=1.CO[C:13](OC)(OC)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH3:10][N:9]1[C:7](=[S:8])[N:6]2[N:5]=[CH:4][N:3]=[C:2]2[N:1]=[C:13]1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

参加物

3

反応物 2

HCID 69720Trimethyl orthobeznoateHCID 32648395-amino-N-methyl-1,2,4-triazole-1-carbothioamide

生成物 1

HCID 10514375HCID 10514375、化合物収率 66%

実験手順

The synthesis method of Example 96 was applied. The compound (1.50 g) obtained in Example 29 and trimethylorthobenzoate (5.0 ml) were used. The mixture was reacted at 150° C. for 2 hours. The resulting crystals were collected by filtration and purified by a method similar to the method of Example 98, whereby crystals (1.53 mg) were obtained (yield 66%). The crystals were recrystallized from methanol to give colorless transparent plate crystals.

後処理

  1. customThe synthesis method of Example 96
  2. customThe mixture was reacted at 150° C. for 2 hours
  3. filtrationThe resulting crystals were collected by filtration
  4. custompurified by a method similar to the method of Example 98

出典と根拠

ORDレコード
ord-c16ddba7f3e64e3a9d501a12477c5174
出典データセット
uspto-grants-1998_05
特許番号
US05750545

反応ノート

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