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Methane → HCID 178516151、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methane | HCID 297 | — |
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Phenylhydrazine | HCID 7516 | — |
| 反応物 | Ethyl 4,4,4-trifluoroacetoacetate | HCID 67793 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | HCID 178516151 | HCID 178516151 | 79.3% |
反応手順
A mixture of 44 ml (0.3 mol) of ethyl trifluoroacetoacetate and 33 mL (335.4 mmol) of phenylhydrazine in 60 ml of methanol containing 6 ml of conc. HCl solution was refluxed with stirring for 1.5 hours. After adding activated charcoal with stirring, the hot mixture was filtered. The residue was washed with methanol (2×70 ml), diluted with water, and the resulting white solid was filtered. The solid was washed with hexane and dried to afford 54.3 g (79%) of 1-phenyl-3-trifluoromethyl-5-hydroxypyrazole as a pale solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05750550 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-98dfa323a2214946b4c50a2aed386206 |
| 出典メモ | uspto-grants-1998_05 |