Potassium Hydroxide → Potassium 4-hydroxy-2,2-dimethylbutyrate

HRID 1289871

反応式

HRID 1289871 の反応式
[CH3:1][C:2]1([CH3:8])[CH2:7][CH2:6][O:5][C:3]1=[O:4].[OH-:9].[K+:10]>O>[K+:10].[OH:5][CH2:6][CH2:7][C:2]([CH3:8])([CH3:1])[C:3]([O-:9])=[O:4]

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 947462,2-Dimethyl-4-butyrolactone

生成物 1

HCID 23712640Potassium 4-hydroxy-2,2-dimethylbutyrate収率 87%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2,2-dimethylbutyrolactone (8.17 g, 71.7 mmol) and KOH (4.02 g,71.7 mmol) in 72 ml of water was refluxed overnight and then the mixture was concentrated in vacuo (50° C.). The crude residual oil was crystallized in ethanol/ether and the resulting white solid product was filtered and dried (100° C./0.1 mm) to afford 10.6 g (87%) of 4-hydroxy-2.2-dimethylbutyric acid monopotassium salt.

後処理

  1. temperaturewas refluxed overnight
  2. concentrationthe mixture was concentrated in vacuo (50° C.)
  3. customThe crude residual oil was crystallized in ethanol/ether
  4. filtrationthe resulting white solid product was filtered
  5. customdried (100° C./0.1 mm)

出典と根拠

ORDレコード
ord-2be3c2878973479eba9f42c26023efa2
出典データセット
uspto-grants-1998_05
特許番号
US05750550

関連ノート

読み込み中…