Diazomethane → Methyl indole-3-carboxylate
反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=[O:11])=[CH:2]1.[N+](=[CH2:15])=[N-]>CCOCC.C(OCC)(=O)C.CO>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([O:12][CH3:15])=[O:11])=[CH:2]1参加物
6
実験手順
Indole-3-carboxylic acid (757 mg, 4.7 mmol, 1.0 eq.) was partially dissolved in a mixture of ether, ethyl acetate and methanol. While stirring, a solution of diazomethane in ether was added until a yellow color persisted. The solvent was removed in vacuo and the remaining white solid was passed through a silica gel column, eluting with dichloromethane to give the title A compound (819 mg), m.p. 147°-149° C.
後処理
- customThe solvent was removed in vacuo
- washeluting with dichloromethane
出典と根拠
- ORDレコード
- ord-1c8c10f69faf4487bee50351a9363e9b
- 出典データセット
- uspto-grants-1995_11
- 特許番号
- US05466704
反応ノート
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