Diazomethane → Methyl indole-3-carboxylate

HRID 128993

反応式

HRID 128993 の反応式
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([OH:12])=[O:11])=[CH:2]1.[N+](=[CH2:15])=[N-]>CCOCC.C(OCC)(=O)C.CO>[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10]([O:12][CH3:15])=[O:11])=[CH:2]1

参加物

6

反応物 2

HCID 9550DiazomethaneHCID 69867Indole-3-Carboxylic Acid

生成物 1

HCID 589098Methyl indole-3-carboxylate

試薬・触媒・溶媒 3

HCID 887Methanol溶媒HCID 3283Diethyl Ether溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

Indole-3-carboxylic acid (757 mg, 4.7 mmol, 1.0 eq.) was partially dissolved in a mixture of ether, ethyl acetate and methanol. While stirring, a solution of diazomethane in ether was added until a yellow color persisted. The solvent was removed in vacuo and the remaining white solid was passed through a silica gel column, eluting with dichloromethane to give the title A compound (819 mg), m.p. 147°-149° C.

後処理

  1. customThe solvent was removed in vacuo
  2. washeluting with dichloromethane

出典と根拠

ORDレコード
ord-1c8c10f69faf4487bee50351a9363e9b
出典データセット
uspto-grants-1995_11
特許番号
US05466704

関連ノート

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