Trimethylsilyldiazomethane → 6-Methoxy-2-methyl-1,3-benzothiazole-7-carbaldehyde

HRID 1290008ノート

反応式

HRID 1290008 の反応式
[OH:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[S:8][C:4]=2[C:3]=1[CH:12]=[O:13].[CH3:14][Si](C=[N+]=[N-])(C)C>CO.C1C=CC=CC=1>[CH3:14][O:1][C:2]1[CH:11]=[CH:10][C:5]2[N:6]=[C:7]([CH3:9])[S:8][C:4]=2[C:3]=1[CH:12]=[O:13]

参加物

5

反応物 2

HCID 167693TrimethylsilyldiazomethaneHCID 189223346-Hydroxy-2-methyl-1,3-benzothiazole-7-carbaldehyde

生成物 1

HCID 189223726-Methoxy-2-methyl-1,3-benzothiazole-7-carbaldehyde

試薬・触媒・溶媒 2

HCID 241Benzene溶媒HCID 887Methanol溶媒

実験手順

6-Hydroxy-2-methyl-benzothiazole-7-carboxaldehyde (75 mg, 0.362 mmol) was taken up in 30% methanol in benzene (7 mL) and treated with (trimethylsilyl)diazomethane (2.0M solution in hexanes) (0.5 mL, 1.0 mmol) for 2 hours at room temperature. The mixture was evaporated, and the title compound was purified by flash chromatography eluting with 25-30% ethyl acetate in hexane.

後処理

  1. customThe mixture was evaporated
  2. customthe title compound was purified by flash chromatography
  3. washeluting with 25-30% ethyl acetate in hexane

出典と根拠

ORDレコード
ord-f8f14fed026942cb864cb3031c4b8dd8
出典データセット
uspto-grants-1998_05
特許番号
US05750549

反応ノート

読み込み中…