Methanesulfonic Acid → HCID 178485753、化合物

HRID 1290078ノート

反応式

HRID 1290078 の反応式
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:50][S:51]([OH:54])(=[O:53])=[O:52]>C(OCC)(=O)C.C(O)C>[CH3:50][S:51]([OH:54])(=[O:53])=[O:52].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 6395Methanesulfonic AcidHCID 178485751HCID 178485751、化合物

生成物 1

HCID 178485753HCID 178485753、化合物収率 82.5%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

The compound (310 mg) obtained in Example 1 was dissolved in ethyl acetate (7 ml) and a solution of methanesulfonic acid (44 mg) in ethyl acetate (5 ml) and ethanol (0.25 ml) was dropwise added. After stirring at room temperature for 3 hours, crystals were collected by filtration and dried under reduced pressure to give 292 mg of the title compound as white crystals (see Table 16).

後処理

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

出典と根拠

ORDレコード
ord-0154a20d7b3042f2a22beff0c0920b96
出典データセット
uspto-grants-1998_05
特許番号
US05750696

反応ノート

読み込み中…