Maleic Acid → HCID 178485754、化合物

HRID 1290079ノート

反応式

HRID 1290079 の反応式
[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:50]([OH:57])(=[O:56])/[CH:51]=[CH:52]\[C:53]([OH:55])=[O:54]>C(OCC)(=O)C.C(O)C>[C:50]([OH:57])(=[O:56])/[CH:51]=[CH:52]\[C:53]([OH:55])=[O:54].[CH:1]1([CH2:7][C@H:8]([NH:19][C:20](=[O:49])[C@H:21]([CH2:43][C:44]2[N:48]=[CH:47][NH:46][CH:45]=2)[N:22]([CH3:42])[C:23](=[O:41])[C@H:24]([CH2:34][C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[NH:25][C:26]([N:28]2[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]2)=[O:27])[C@@H:9]([OH:18])[CH2:10][C@H:11]2[C:15]([CH3:17])([CH3:16])[O:14][CH2:13][O:12]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 2

HCID 444266Maleic AcidHCID 178485751HCID 178485751、化合物

生成物 1

HCID 178485754HCID 178485754、化合物収率 79.8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 8857Ethyl Acetate溶媒2 回

実験手順

The compound (778 mg) obtained in Example 1 was dissolved in ethyl acetate (10 ml) and a solution of maleic acid (132 mg) in ethyl acetate (15.5 ml) and ethanol (1.55 ml) was dropwise added. After stirring overnight at room temperature, crystals were collected by filtration and dried under reduced pressure to give 723 mg of the title compound as white crystals (see Table 17).

後処理

  1. filtrationcrystals were collected by filtration
  2. customdried under reduced pressure

出典と根拠

ORDレコード
ord-902c1afeed5b40b48f9435e57e378e33
出典データセット
uspto-grants-1998_05
特許番号
US05750696

反応ノート

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