Ammonia → HCID 22101782、化合物
反応式
[NH3:1].[Cl:2][C:3]1[C:4](F)=[N:5][C:6]([F:13])=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1>C(O)C>[NH2:1][C:4]1[C:3]([Cl:2])=[CH:8][C:7]([C:9]([F:12])([F:11])[F:10])=[C:6]([F:13])[N:5]=1参加物
4
反応条件
- 温度
- 55 °C
実験手順
12.5.g (0.74 mol) of gaseous ammonia were passed into a stirred mixture of 40 g (0.184 mol) of 3-chloro-2,6-difluoro-5-trifluoromethylpyridine in 200 ml of ethanol in the course of 45 minutes at 50°-60 C. After the reaction mixture had been stirred for 11/2 hours at 55° C., it was cooled and concentrated. The residue was stirred in water, filtered off with suction and dried, giving 36.7 g (93% of theory) of the title compound of m.p. 101°-103° C.
後処理
- temperatureit was cooled
- concentrationconcentrated
- stirringThe residue was stirred in water
- filtrationfiltered off with suction
- customdried
出典と根拠
- ORDレコード
- ord-dd21ea42029e440e87b8243742cd983f
- 出典データセット
- uspto-grants-1998_05
- 特許番号
- US05750705
反応ノート
読み込み中…