Potassium Carbonate → 8-[2-(2,6-Dichlorophenyl)ethyloxy]-2-methylimidazo[1,2-a]pyridine

HRID 1290159

反応式

HRID 1290159 の反応式
[OH:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1.[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:14]=1[CH2:20][CH2:21]OS(C)(=O)=O.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[Cl:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[C:14]=1[CH2:20][CH2:21][O:1][C:2]1[C:3]2[N:4]([CH:8]=[C:9]([CH3:11])[N:10]=2)[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 8209532-Methylimidazo[1,2-a]pyridin-8-olHCID 155656222-(2,6-Dichlorophenyl)ethyl methanesulfonate

生成物 1

HCID 189233368-[2-(2,6-Dichlorophenyl)ethyloxy]-2-methylimidazo[1,2-a]pyridine収率 23.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
70 °C

実験手順

A mixture of 8-hydroxy-2-methylimidazo[1,2-a]pyridine (296 mg), 1,3-dichloro-2-(2-mesyloxyethyl)benzene (645 mg) and potassium carbonate (828 mg) in N,N-dimethylformamide (12 ml) was stirred for 6 hours at 70° C. The mixture was treated according to a similar manner to that of Preparation 16 to give 8-[2-(2,6-dichlorophenyl)ethyloxy]-2-methylimidazo[1,2-a]pyridine (150 mg).

後処理

  1. additionThe mixture was treated
  2. customof Preparation 16

出典と根拠

ORDレコード
ord-e000f68925e64e869fe194b41ff6db91
出典データセット
uspto-grants-1998_05
特許番号
US05750699

関連ノート

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