Hydrochloric Acid → Methyl(4-(4-bromobenzylamino)-2,6-dimethylpyrimidin-5-yl)ketone
反応式
[Br:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][NH:7][C:8]2[C:13]([C:14]([O:16]CC)=[CH2:15])=[C:12]([CH3:19])[N:11]=[C:10]([CH3:20])[N:9]=2)=[CH:4][CH:3]=1.Cl>CC(C)=O>[CH3:15][C:14]([C:13]1[C:8]([NH:7][CH2:6][C:5]2[CH:4]=[CH:3][C:2]([Br:1])=[CH:22][CH:21]=2)=[N:9][C:10]([CH3:20])=[N:11][C:12]=1[CH3:19])=[O:16]参加物
4
実験手順
A solution of 4-(4-bromobenzylamino)-2,6-dimethyl-5-(1-ethoxyvinyl)pyrimidine (2.72 g, 7.51 mmol), 1N HCl (8.3 mL), and acetone (8 mL) was heated under reflux for 2.5 h. The acetone was removed under reduced pressure and the aqueous phase was adjusted to pH 4 with 1N KOH. The resultant white precipitate was collected by filtration to give 2.24 g (89%) of product as a white solid. An analytical sample was recrystallized from hexane, mp 78°-80° C.