2-Methoxynaphthalene → Methyl 2-hydroxy-2-(6-methoxynaphthalen-2-yl)propanoate

HRID 1290271ノート

反応式

HRID 1290271 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[C:13]([O:18][CH3:19])(=[O:17])[C:14]([CH3:16])=[O:15].[Cl-].[Al+3].[Cl-].[Cl-]>ClCCl>[OH:15][C:14]([C:8]1[CH:7]=[CH:6][C:5]2[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=2)[CH:9]=1)([CH3:16])[C:13]([O:18][CH3:19])=[O:17]

参加物

5

反応物 3

HCID 71192-Methoxynaphthalene2 回HCID 11748Methyl pyruvateHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 11043497Methyl 2-hydroxy-2-(6-methoxynaphthalen-2-yl)propanoate収率 52%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

A mixture of 2-methoxynaphthalene (20,0 g, 126 mmol) and methyl pyruvate (19,3 g, 190 mmol) in dichloromethane (100 mL) was added to a suspension of aluminium chloride (25,3 g, 190 mmol) in dichloromethane (100 mL) at 6° C. over 140 minutes. The solution was stirred for a further 15 minutes at this temperature and added to ice/water. Methyl 2-hydroxy-2-(6-methoxynaphth-2-yl)propionate (52% yield) and 2-methoxynaphthalene (34% recovery) were the primary components of the reaction mixture.

出典と根拠

ORDレコード
ord-02447c5588774be8b7233e763d628dc0
出典データセット
uspto-grants-1998_05
特許番号
US05750764

反応ノート

読み込み中…