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Nabumetone → 4-(5-Bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Nabumetone | HCID 4409 | — |
| 反応物 | 1-(5-Bromo-6-methoxynaphthalen-2-yl)ethan-1-one | HCID 622178 | — |
| 生成物 | 4-(5-Bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one | HCID 70179405 | — |
反応手順
New process for the synthesis of the antiinflammatory drug known as nabumetone that consists in reacting 2-acetyl-5-bromo-6-methoxynaphthalene with an alkyl acetate in presence of an alkaline alcoholate to get 4-(5-bromo-6-methoxy-2-naphthyl)-4-hydroxybut-3-en-2-one that by catalytic hydrogenation in a polar solvent and in presence of a base gives 4-(6-methoxy-2-naphthyl)butan-2-one known as nabumetone.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05750793 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-37bfe041c442425998114372078aa3dc |
| 出典メモ | uspto-grants-1998_05 |