Potassium → 4-Methyl-6-nitro-1H-indole

HRID 1290565ノート

反応式

HRID 1290565 の反応式
[K].C(OCC)(=O)C([O-])=O.[CH3:10][C:11]1[C:16]([CH3:17])=[CH:15][C:14]([N+:18]([O-:20])=[O:19])=[CH:13][C:12]=1[N:21]=[CH:22]OC>CN(C)C=O>[CH3:17][C:16]1[CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=[C:12]2[C:11]=1[CH:10]=[CH:22][NH:21]2

参加物

5

反応物 3

HCID 5462222PotassiumHCID 21218303HCID 21218303、化合物HCID 21943339Ethanedioic acid, monoethyl ester

生成物 1

HCID 212182864-Methyl-6-nitro-1H-indole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

反応条件

温度
40 °C

実験手順

A solution of 31 g of potassium ethoxylate, 51 ml of ethyl oxalate and 0.25 l of dimethylformamide is added to a solution of methyl N-(2,3-dimethyl-5-nitrophenyl)formimidate (52 g) in 0.37 l of dimethylformamide. The temperature of the mixture is raised to 40° C. for 3 hours. The precipitate is filtered off and washed with water. The precipitate is taken up in hot isopropyl ether and then filtration is carried out.

後処理

  1. filtrationThe precipitate is filtered off
  2. washwashed with water
  3. filtrationfiltration

出典と根拠

ORDレコード
ord-22a241a7c279457799d51da4b15e6f1e
出典データセット
uspto-grants-1998_05
特許番号
US05752982

反応ノート

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