化工社化工社 化学情報印刷レポート · 研究参考用
Water → 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | N-Bromomethylsaccharin | HCID 15225519 | — |
| 反応物 | Methyltriazabicyclodecene | HCID 77320394 | — |
| 反応物 | 2-Hydroxy-3-chloropyrido[1,2-a]pyrimidine-4-one | HCID 135758979 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin | HCID 10763054 | 65% |
反応手順
To a mixture of 2-hydroxy-3-chloropyrido[1,2-a]pyrimidine-4-one (0.324 g), and methyltriazabicyclodecene (0.24 mL) in DMF (15 mL) was added 2-bromomethylsaccharin (0.414 g). The mixture was stirred overnight, poured into water and the precipitate which formed was collected by filtration and recrystallized from DMF to afford 0.371 g (65%) of 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05466701 |
| 出典データセット | uspto-grants-1995_11 |
| ORD ID | ord-bdefed0c38144a238c0018a84a3d9e58 |
| 出典メモ | uspto-grants-1995_11 |