Water → 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin

HRID 129062

反応式

HRID 129062 の反応式
[OH:1][C:2]1[N:3]=[C:4]2[CH:13]=[CH:12][CH:11]=[CH:10][N:5]2[C:6](=[O:9])[C:7]=1[Cl:8].CN1NCCCCCCC(C2CCCCCCCCC=2)=N1.Br[CH2:36][N:37]1[C:47](=[O:48])[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[S:38]1(=[O:40])=[O:39].O>CN(C=O)C>[Cl:8][C:7]1[C:6](=[O:9])[N:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]2=[N:3][C:2]=1[O:1][CH2:36][N:37]1[C:47](=[O:48])[C:46]2[C:41](=[CH:42][CH:43]=[CH:44][CH:45]=2)[S:38]1(=[O:39])=[O:40]

参加物

6

反応物 4

HCID 962WaterHCID 15225519N-BromomethylsaccharinHCID 77320394MethyltriazabicyclodeceneHCID 1357589792-Hydroxy-3-chloropyrido[1,2-a]pyrimidine-4-one

生成物 1

HCID 107630542-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin収率 65%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a mixture of 2-hydroxy-3-chloropyrido[1,2-a]pyrimidine-4-one (0.324 g), and methyltriazabicyclodecene (0.24 mL) in DMF (15 mL) was added 2-bromomethylsaccharin (0.414 g). The mixture was stirred overnight, poured into water and the precipitate which formed was collected by filtration and recrystallized from DMF to afford 0.371 g (65%) of 2-[3-chloro-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-yl]oxymethyl-saccharin.

後処理

  1. customthe precipitate which formed
  2. filtrationwas collected by filtration
  3. customrecrystallized from DMF

出典と根拠

ORDレコード
ord-bdefed0c38144a238c0018a84a3d9e58
出典データセット
uspto-grants-1995_11
特許番号
US05466701

関連ノート

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