Methane → HCID 18916577、化合物

HRID 1290654ノート

反応式

HRID 1290654 の反応式
[CH3:1][N:2]1[CH:10]2[CH:6]([CH2:7][C:8]([P:15]([OH:18])(=[O:17])[OH:16])([P:11]([OH:14])(=[O:13])[OH:12])[CH2:9]2)[CH2:5][CH2:4][CH2:3]1.[C:19]([S:22][CH2:23][CH2:24][Br:25])(=[O:21])[CH3:20].C>O.CS(C)=O>[Br-:25].[P:11]([C:8]1([P:15]([OH:16])([OH:18])=[O:17])[CH2:9][CH:10]2[CH:6]([CH2:5][CH2:4][CH2:3][N+:2]2([CH2:24][CH2:23][S:22][C:19](=[O:21])[CH3:20])[CH3:1])[CH2:7]1)([OH:12])([OH:14])=[O:13]

参加物

6

反応物 3

HCID 297MethaneHCID 5230361-[(2-Bromoethyl)sulfanyl]ethan-1-oneHCID 14518763HCID 14518763、化合物

生成物 1

HCID 18916577HCID 18916577、化合物

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

Octahydro-1-methyl-1-pyrindine-6,6-diphosphonic acid (0.12 mmol) is dissolved in a mixture of water (25 ml) and DMSO (5 ml). To this is added 2-acetylthioethyl bromide (0.60 mmol) and the reaction mixture is heated at 60° for 24 hours. The reaction mixture is cooled, treated with charcoal, filtered and concentrated under reduced pressure. The crude residue is triturated with diethylether and the product can be obtained by recrystallizing the solid residue in water and isopropanol.

後処理

  1. temperaturethe reaction mixture is heated at 60° for 24 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe crude residue is triturated with diethylether
  6. customthe product can be obtained
  7. customby recrystallizing the solid residue in water

出典と根拠

ORDレコード
ord-f301d39577144ce3ae58d6ad92ae7d2d
出典データセット
uspto-grants-1998_05
特許番号
US05753634

反応ノート

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