Methane → Octahydro-6,6-diphosphono-1-(2-mercaptoethyl)-1-methyl-1-pyrindinium chloride

HRID 1290655ノート

反応式

HRID 1290655 の反応式
[Br-].[P:2]([C:6]1([P:22]([OH:25])([OH:24])=[O:23])[CH2:14][CH:13]2[CH:8]([CH2:9][CH2:10][CH2:11][N+:12]2([CH2:16][CH2:17][S:18]C(=O)C)[CH3:15])[CH2:7]1)([OH:5])([OH:4])=[O:3].C.[ClH:27]>>[Cl-:27].[P:22]([C:6]1([P:2]([OH:5])([OH:4])=[O:3])[CH2:14][CH:13]2[CH:8]([CH2:9][CH2:10][CH2:11][N+:12]2([CH2:16][CH2:17][SH:18])[CH3:15])[CH2:7]1)([OH:24])([OH:25])=[O:23]

参加物

4

反応物 3

HCID 297MethaneHCID 313Hydrochloric AcidHCID 18916577HCID 18916577、化合物

生成物 1

HCID 86752569Octahydro-6,6-diphosphono-1-(2-mercaptoethyl)-1-methyl-1-pyrindinium chloride

実験手順

Octahydro-6,6-diphosphono-1-(2-acetylthioethyl)-1-methyl-1-pyrindinium bromide (0.05 mmol) is heated at reflux in 6N HCl (15 ml) under an atmosphere of nitrogen. The reaction mixture is cooled, treated with charcoal and filtered. The resulting filtrate is concentrated under reduced pressure. The resulting solid residue can be recrystallized from water and ethanol to provide the desired product.

後処理

  1. temperatureThe reaction mixture is cooled
  2. filtrationfiltered
  3. concentrationThe resulting filtrate is concentrated under reduced pressure
  4. customThe resulting solid residue can be recrystallized from water and ethanol

出典と根拠

ORDレコード
ord-a7c1acfee915465a822acf10115a7627
出典データセット
uspto-grants-1998_05
特許番号
US05753634

反応ノート

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