Ammonia → Methoxymalonamic acid
反応式
[CH3:1][O:2][CH:3]([C:8]([O-:10])=O)[C:4]([O:6]C)=[O:5].[NH3:11]>C(Cl)Cl>[CH3:1][O:2][CH:3]([C:8]([NH2:11])=[O:10])[C:4]([OH:6])=[O:5]参加物
4
実験手順
A solution of 10.4 g of monomethyl methoxymalonate in 70 ml of methylene chloride was added dropwise at -10° C. to 26 ml of 25 percent aqueous ammonia. After stirring the mixture was evaporated and the residue was dissolved in water and chromatographed on a cation exchanger with water. The eluate was concentrated and the residue was triturated with diethyl ether and filtered off. The precipitate was washed with water and dried. There were obtained 8.9 g of methoxymalonamic acid, m.p. 128°-130° C.
後処理
- customwas evaporated
- dissolutionthe residue was dissolved in water
- customchromatographed on a cation exchanger with water
- concentrationThe eluate was concentrated
- customthe residue was triturated with diethyl ether
- filtrationfiltered off
- washThe precipitate was washed with water
- customdried
出典と根拠
- ORDレコード
- ord-ba2ee0b710fe47d69c878baff79ad264
- 出典データセット
- uspto-grants-1995_11
- 特許番号
- US05466708
反応ノート
読み込み中…