1-Chloro-1-penten-3-one → 7-Ethyl-1,2,4-triazolo[1,5-a]pyrimidine

HRID 1290801ノート

反応式

HRID 1290801 の反応式
[NH2:1][C:2]1[N:6]=[CH:5][NH:4][N:3]=1.Cl[CH:8]=[CH:9][C:10](=O)[CH2:11][CH3:12]>C(O)(=O)C>[CH2:11]([C:10]1[N:3]2[N:4]=[CH:5][N:6]=[C:2]2[N:1]=[CH:8][CH:9]=1)[CH3:12]

参加物

4

反応物 2

HCID 30420161-Chloro-1-penten-3-oneHCID 178418311HCID 178418311、化合物

生成物 1

HCID 189193537-Ethyl-1,2,4-triazolo[1,5-a]pyrimidine

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

A mixture of 3-amino-1,2,4-triazole (11.74 g) and 1-chloro-1-penten-3-one (16.5 g) in acetic acid (225 ml) was heated under reflux for 45 minutes. The reaction mixture was cooled, poured onto ice and extracted with dichloromethane. The organic layer was dried and the solvent was evaporated under reduced pressure to give 7-ethyl-1,2,4-triazolo[1,5-a]pyrimidine. Yield 11.72 g.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 45 minutes
  3. temperatureThe reaction mixture was cooled
  4. additionpoured onto ice
  5. extractionextracted with dichloromethane
  6. customThe organic layer was dried
  7. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-0aa344644dc74068b60e34c3e9ed934b
出典データセット
uspto-grants-1998_05
特許番号
US05753665

反応ノート

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