Potassium Hydroxide → HCID 13565856、化合物

HRID 1290884ノート

反応式

HRID 1290884 の反応式
Cl.[NH2:2][CH:3]1[CH2:9][CH:8]2[NH:10][CH:5]([CH2:6][CH2:7]2)[CH2:4]1.[OH-].[K+]>C(O)C>[NH2:2][CH:3]1[CH2:4][CH:5]2[NH:10][CH:8]([CH2:7][CH2:6]2)[CH2:9]1

参加物

4

反応物 2

HCID 14797Potassium HydroxideHCID 18919578HCID 18919578、化合物

生成物 1

HCID 13565856HCID 13565856、化合物収率 35.7%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒2 回

実験手順

After completion of the hydrogenation, insoluble matters were filtered off and 40 ml of conc. hydrochloric acid was added to the filtrate. The solvent was distilled off under vacuum and the residue was recrystallized from ethanol to give 8.3 g of 3-amino-8-azabicyclo[3.2.1]octane hydrochloride. After 8.3 g of the hydrochloride was added to 100 ml of ethanol, a solution of 5.2 g of potassium hydroxide in 50 ml of ethanol was added to the mixture followed by stirring at room temperature for 3 hours. Insoluble matters were filtered off and the solvent was then distilled off to give 2.3 g of 3-amino-8-azabicyclo[3.2.1]octane.

後処理

  1. filtrationInsoluble matters were filtered off
  2. distillationthe solvent was then distilled off

出典と根拠

ORDレコード
ord-f61dbc2b477d4411ac458a90a82b4fd3
出典データセット
uspto-grants-1998_05
特許番号
US05753673

反応ノート

読み込み中…