化工社化工社 化学情報印刷レポート · 研究参考用
Diethyl Malonate → Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Malonate | HCID 7761 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 2-Isopropylaminobenzaldehyde hydrochloride | HCID 18919624 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate | HCID 15468682 | 147.4% |
反応手順
A solution of 133.7 g of 2-isopropylaminobenzaldehyde hydrochloride, 200 g of diethyl malonate, 70 ml of piperidine, 70 ml of acetic acid, 50 g of potassium carbonate and 1.5 liter of toluene was heated to reflux for 10 hours. The reaction solution was washed with water and then with saturated sodium hydrogencarbonate aqueous solution, and dried over anhydrous magnesium sulfate. The solvent was distilled off to give 256 g of ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate as the crude product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05753673 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-0b38fcc32af04d938445b2572f71a4d6 |
| 出典メモ | uspto-grants-1998_05 |