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Acetic Acid → Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Diethyl Malonate | HCID 7761 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 反応物 | 2-((Propan-2-yl)amino)benzaldehyde | HCID 11041035 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate | HCID 15468682 | 163.7% |
反応手順
A solution of 20.0 g of 2-isopropylaminobenzaldehyde, 29.4 g of diethyl malonate, 10 ml of piperidine, 10 ml of acetic acid and 500 ml of toluene was heated to reflux for 13 hours. The reaction solution was washed with water and then with saturated sodium hydrogencarbonate aqueous solution, and dried over anhydrous magnesium sulfate. The solvent was distilled off to give 52 g of ethyl 1-isopropyl-2-oxo-1,2-dihydro-3-quinolinecarboxylate as the crude product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05753673 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-25437f40d43f43cbb58bd11a5bdc9e43 |
| 出典メモ | uspto-grants-1998_05 |