Methanol → 1-Benzyl-piperidin-4-yl 2-chloro-benzoate hydrochloride

HRID 1291082ノート

反応式

HRID 1291082 の反応式
[Cl:1][C:2]1[CH:23]=[CH:22][CH:21]=[CH:20][C:3]=1[C:4]([O:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9][CH2:8]1)=[O:5].CO>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:23]=[CH:22][CH:21]=[CH:20][C:3]=1[C:4]([O:6][CH:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH2:9][CH2:8]1)=[O:5]

参加物

4

反応物 2

HCID 887MethanolHCID 189197891-Benzyl-piperidin-4-yl 2-chloro-benzoate

生成物 1

HCID 189199271-Benzyl-piperidin-4-yl 2-chloro-benzoate hydrochloride収率 172.9%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

0.1 g (0.0003 mol) of 1-benzyl-piperidin-4-yl 2-chloro-benzoate was dissolved in 5 ml of ether and 0.5 ml of methanol and treated with 1 ml of 1N ethereal HCI. The mixture was stirred for 2 hrs. and the resulting precipitate was filtered off, washed with ether and dried. 0.095 g (86%) of 1-benzyl-piperidin-4-yl 2-chloro-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 200°-202°.

後処理

  1. filtrationand the resulting precipitate was filtered off
  2. washwashed with ether
  3. customdried

出典と根拠

ORDレコード
ord-a6b7eecbefde412e805233cb6654df64
出典データセット
uspto-grants-1998_05
特許番号
US05753679

反応ノート

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