Methanol → HCID 18919782、化合物

HRID 1291084ノート

反応式

HRID 1291084 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[C:5]([O:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=[O:6].CO>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([CH:21]=[CH:22][CH:23]=1)[C:5]([O:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)=[O:6]

参加物

4

反応物 2

HCID 887MethanolHCID 18919783HCID 18919783、化合物

生成物 1

HCID 18919782HCID 18919782、化合物収率 172.9%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

0.1 g (0.0003 mol) of 1-benzyl-piperidin-4-yl 3-chloro-benzoate was dissolved in 5 ml of ether and 0.5 ml of methanol and treated with 1 ml of 1N ethereal HCI. The mixture was stirred for 2 hrs. and the resulting precipitate was filtered off, washed with ether and dried. 0.095 g (86%) of 1-benzyl-piperidin-4-yl 3-chloro-benzoate hydrochloride (1:1) was obtained as white crystals, m.p. 212°-213°.

後処理

  1. filtrationand the resulting precipitate was filtered off
  2. washwashed with ether
  3. customdried

出典と根拠

ORDレコード
ord-efe8d3556c774342949dfb8df30c0c6e
出典データセット
uspto-grants-1998_05
特許番号
US05753679

反応ノート

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