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Triethylamine → 1-Benzyl-piperidin-4-yl 3-iodo-benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 3-Iodobenzoyl chloride | HCID 74378 | — |
| 反応物 | 1-Benzylpiperidin-4-ol | HCID 78461 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Benzyl-piperidin-4-yl 3-iodo-benzoate | HCID 18919862 | 76% |
反応手順
1.21 g (0.0063 mol) of 1-benzyl-4-hydroxypiperidine and 0.874 ml (0.0063 mol) of triethylamine were dissolved in 80 ml of toluene and treated with 1.6 g (0.006 mol) of 3-iodo-benzoyl chloride. The mixture was boiled at reflux for 6 hrs., the precipitate was filtered off and the filtrate was concentrated. The residue was chromatographed over silica gel with ethyl acetate/hexane (1:2). 1.9 g (76%) of 1-benzyl-piperidin-4-yl 3-iodo-benzoate were obtained as yellowish crystals; m.p. 101°-103°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05753679 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-a9a5a14b86064033b64ff2fb81d7da3c |
| 出典メモ | uspto-grants-1998_05 |