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Triethylamine → 1-Benzyl-piperidin-4-yl 2-methoxy-benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Benzylpiperidin-4-ol | HCID 78461 | — |
| 反応物 | 2-Methoxybenzoyl chloride | HCID 88969 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Benzyl-piperidin-4-yl 2-methoxy-benzoate | HCID 18919786 | 69% |
反応手順
1.41 g (0.00733 mol) of 1-benzyl-4-hydroxypiperidine and 1.8 ml (0.0129 mol) of triethylamine were dissolved in 50 ml of toluene and treated with 0.79 ml (0.00586 mol) of 2-methoxy-benzoyl chloride. The mixture was boiled at reflux for 2 hrs., the precipitate was filtered off and the filtrate was concentrated. The residue was chromatographed over silica gel with ethyl acetate/hexane (1:2). 1.31 g (69%) of 1-benzyl-piperidin-4-yl 2-methoxy-benzoate were obtained as a yellowish oil. MS: me/e=326 (C20H24NO3 +).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05753679 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-0cd03ccf5b6c4bdf9ce9ae0f7e0f9d26 |
| 出典メモ | uspto-grants-1998_05 |