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Triethylamine → 1-Benzyl-piperidin-4-yl 4-bromo-2-nitro-benzoate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1-Benzylpiperidin-4-ol | HCID 78461 | — |
| 反応物 | 4-Bromo-2-nitrobenzoyl chloride | HCID 18919880 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Benzyl-piperidin-4-yl 4-bromo-2-nitro-benzoate | HCID 18919850 | 28% |
反応手順
0.482 g (0.0025 mol) of 1-benzyl-4-hydroxypiperidine and 0.62 ml (0.0045 mol) of triethylamine were dissolved in 20 ml of toluene and treated with the 4-bromo-2-nitro-benzoyl chloride obtained under a) dissolved in 5 ml of toluene. The mixture was boiled at reflux for 6 hrs., the precipitate was filtered off and the filtrate was concentrated. The residue was chromatographed over silica gel with ethyl acetate/hexane (1:7 and 1:4). 0.3 g (28%) of 1-benzyl-piperidin-4-yl 4-bromo-2-nitro-benzoate was obtained as a brown oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05753679 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-bb5883caa53a485ebe71cebcd34d1148 |
| 出典メモ | uspto-grants-1998_05 |