3-Bromobenzyl bromide → 1-(3-Bromobenzyl)piperidin-4-ol

HRID 1291129ノート

反応式

HRID 1291129 の反応式
[OH:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12]Br>CN(C)C=O>[Br:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=1)[CH2:12][N:5]1[CH2:6][CH2:7][CH:2]([OH:1])[CH2:3][CH2:4]1

参加物

4

反応物 2

HCID 699793-Bromobenzyl bromideHCID 79341Piperidin-4-ol

生成物 1

HCID 7652181-(3-Bromobenzyl)piperidin-4-ol収率 96.2%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

0.202 g (0.002 mol) of 4-hydroxypiperidine and 0.55 g (0.0022 mol) of 3-bromobenzyl bromide were dissolved in 5 ml of dimethylformamide and stirred at room temperature for 2 hrs. The solvent was distilled off and the residue was taken up in dichloromethane and washed with saturated bicarbonate solution and sodium chloride solution. The organic phase was dried over sodium sulfate and concentrated. 0.52 g (96%) 1-(3-bromo-benzyl)-piperidin-4-ol was obtained as a brown oil. MS: me/e (% basic peak)=271, 269 (C12H16BrNO+, 26, 26.6), 270, 268 (25.5, 22), 171, 169 (47, 48.3), 114 (76.6), 100 (100).

後処理

  1. distillationThe solvent was distilled off
  2. washwashed with saturated bicarbonate solution and sodium chloride solution
  3. dry with materialThe organic phase was dried over sodium sulfate
  4. concentrationconcentrated

出典と根拠

ORDレコード
ord-e9bc74bbf57b4aff85256636a10ac1a1
出典データセット
uspto-grants-1998_05
特許番号
US05753679

反応ノート

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