HCID 18919774、化合物 → HCID 18919904、化合物
反応式
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Br:22])=[CH:18][CH:17]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][CH:3]=1>CCOCC>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH:9]2[CH2:10][CH2:11][N:12]([CH2:15][C:16]3[CH:17]=[CH:18][C:19]([Br:22])=[CH:20][CH:21]=3)[CH2:13][CH2:14]2)=[O:7])=[CH:23][CH:24]=1参加物
3
実験手順
0.204 g (0.00055 mol) of 1-(4-bromo-benzyl)-piperidin-4-yl 4-chloro-benzoate was dissolved in 15 ml of ether, filtered, diluted with 0.75 ml of methanol and treated with 5ml of 1N ethereal HCI. The separated precipitate was filtered off and dried. 0.188 g (83.6%) of 1-(4-bromo-benzyl)-piperidin-4-yl 4-chloro-benzoate hydrochloride (1:1) was obtained as white crystals; m.p. 240°-242°.
後処理
- filtrationfiltered
- additiondiluted with 0.75 ml of methanol
- additiontreated with 5ml of 1N ethereal HCI
- filtrationThe separated precipitate was filtered off