化工社化工社 化学情報印刷レポート · 研究参考用
Isopropyl iodide → 7-[4-(4-Chlorobenzoyl)benzyl]-1-isopropyl-3-methylxanthine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Isopropyl iodide | HCID 6362 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Methyl-7-[4-(4-chlorobenzoyl)benzyl]xanthine | HCID 18918801 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 7-[4-(4-Chlorobenzoyl)benzyl]-1-isopropyl-3-methylxanthine | HCID 18919245 | 6.3% |
反応手順
A solution of 3-methyl-7-[4-(4-chlorobenzoyl)-benzyl]xanthine (544 mg), potassium carbonate (202 mg) and isopropyl iodide (356 mg) in DMF (10 ml) was stirred at 60° C. for 5 hours. This reaction mixture was poured in water and extracted with ethyl acetate. The extract was washed with water, dried and concentrated. The residue was purified by silica gel column chromatography (hexane: ethyl acetate =1:1) and recrystallized from acetone-hexane to provide the title compound as colorless solid (38 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05753664 |
| 出典データセット | uspto-grants-1998_05 |
| ORD ID | ord-bcf7b3611c324a34a886238f54b510c8 |
| 出典メモ | uspto-grants-1998_05 |