Sodium Dithionite → 2,2'-Bithiophene-5-carboxylic acid

HRID 1291580

反応式

HRID 1291580 の反応式
[O-]Cl.[Na+].[C:4]([C:7]1[S:11][C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:9][CH:8]=1)(=[O:6])C.[O-:17]S(S([O-])=O)=O.[Na+].[Na+]>>[C:4]([C:7]1[S:11][C:10]([C:12]2[S:13][CH:14]=[CH:15][CH:16]=2)=[CH:9][CH:8]=1)([OH:6])=[O:17]

参加物

4

反応物 3

HCID 24489Sodium DithioniteHCID 6064225-Acetyl-2,2'-bithienylHCID 23665760Sodium Hypochlorite

生成物 1

HCID 1509652,2'-Bithiophene-5-carboxylic acid

実験手順

35 ml of NaOCl solution was heated to 55° C. and 5acetyl-2,2'-bithiophene was then added and stirred at 60°-70° C. for 2 hours. Then the reaction solution was cooled by ice bath and aqueous Na2S2O4 solution was added for removing the residual NaOCl. The reaction mixture was acidified by HCl(aq) and filtered to obtain golden product. The product was further recrystallized with 95% ethanol. The melting point of the product was 183-184%.

後処理

  1. temperatureThen the reaction solution was cooled by ice bath
  2. customfor removing the residual NaOCl
  3. filtrationfiltered
  4. customto obtain golden product
  5. customThe product was further recrystallized with 95% ethanol

出典と根拠

ORDレコード
ord-085b021deec3432fa8b44fe999245988
出典データセット
uspto-grants-1998_05
特許番号
US05753692

関連ノート

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