[C:1]1(=[O:6])O[CH2:4][CH2:3][CH2:2]1.[CH3:7][NH:8][CH2:9][C@@H:10]([C@H:12]([C@@H:14]([C@@H:16]([CH2:18][OH:19])[OH:17])[OH:15])[OH:13])[OH:11].[OH:20]CCCC(O)=O>O>[OH:20][CH:2]([CH2:3][CH3:4])[C:1]([O:15][C@H:14]([C@@H:16]([CH2:18][OH:19])[OH:17])[C@H:12]([OH:13])[C@@H:10]([OH:11])[CH2:9][NH:8][CH3:7])=[O:6]500 ml (565 g, 6.56 mol) of gamma-butyrolactone are placed in 1.8 l of water. 1.28 kg (6.56 mol) of methylglucamine are added to the solution obtained. The mixture is then heated to 60° C. for 8 hours. The pH value falls over this period from an initial value of 11 to 7.5. The volume of the solution obtained is then adjusted to 3.4 l by the addition of water (approximately 200 ml) in order to achieve a concentration of 2 g of gamma-hydroxybutyric acid in 10 ml of solution.
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