関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | Sulfuric Acid | HCID 1118 | — |
| 反応物 | Sodium Carbonate | HCID 10340 | — |
| 反応物 | 12-Aminododecanoic Acid | HCID 69661 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | Methyl 12-aminododecanoate | HCID 3665980 | 95% |
反応手順
To a 3-l flask equipped with a stirrer, 200.0 g (0.93 mol) of 12-aminododecanoic acid, 600 g of methanol and 100 g (1.0 mol) of sulfuric acid were charged, followed by stirring at 60° C. for 5 hours. After the reaction mixture was allowed to cool down, it was diluted with methylene chloride, followed by neutralization with an aqueous solution of sodium carbonate. The solvent was distilled off under reduced pressure, followed by purification by chromatography on an alumina short column, whereby 201.7 g of the title compound (7-a) were obtained (yield: 95%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05753707 |
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| 出典データセット | uspto-grants-1998_05 |
|---|
| ORD ID | ord-65d1920ed434425f8e8e578931e129a0 |
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| 出典メモ | uspto-grants-1998_05 |
|---|
